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Midterm

PAT 20A/B Study Guide - Midterm Guide: Premenstrual Dysphoric Disorder, Irritable Bowel Syndrome, Orthostatic Hypotension


Department
Pathotherapeutics
Course Code
PAT 20A/B
Professor
Leo Michelis
Study Guide
Midterm

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1
WEEK 5 (WINTER) Mood Disorders/Depression
NAME + CLASS
ACTION + INDICATION
SIDE EFFECTS & INTERACTIONS
NURSING IMPLICATIONS
fluoxetine hydrochloride
( Selective serotonin receptor
inhibitors)
p. 623
Trade Name: Prozac, Sarafem
Class:
Therapeutic Class:
Antidepressants
Pharmacologic Class: SSRIs
Route of Administration
PO
Avoid giving in the afternoon
causes nervousness and insomnia
Mechanism of Action:
Thought to be linked to drug’s
inhibition of CNS neuronal uptake
of serotonin
Indication:
Depression, obsessive-
compulsive disorder (OCD)
Maintenance therapy for
depression
Short-term and long-term
treatment of bulimia
Short-term treatment of panic
disorder
Depressive episodes associated
with bipolar I disorder
Treatment-resistant depression
Posttraumatic stress disorder
Premenstrual dysphoric disorder
Borderline personality disorder
Irritable bowel syndrome
Half Life:
Acute administration 2-3 days
Long-term administration 4-6 days
Common SE:
Nervousness, drowsiness, tremor, fever
Important ones (bolded):
Suicidal behavior, respiratory distress
Interactions:
Aspirin, NSAIDs increase risk of
GI bleeding
Beta blockers may increase
levels of these drugs
Warfarin increase risk of
bleeding
Lab Test Results
may decrease sodium level
Cautious Use
pts at high risk for suicide
history of DM, seizures, mania, hepatic, renal,
or CV disease
third semester of pregnancy neonatal
complications
Only approved in children with MAJOR
depressive disorder and OCD
Contraindications:
Not approved for children younger than 7
Nursing Considerations
Max daily dose is 80 mg
Give in the morning
citalopram( Selective serotonin
receptor inhibitors)
p. 340
Trade Name: Celexa
Class:
Therapeutic Class:
Antidepressants
Pharmacologic Class: SSRIs
Route of Administration
PO
Mechanism of Action:
Probably linked to potentiation of
serotonergic activity in the CNS
resulting from inhibition of
neuronal reuptake of serotonin
Indication:
Depression
Obsessive-compulsive disorder
Half Life: 35 hours
Common SE:
Insomnia, decreased or increased weight,
increased sweating, increased saliva,
orthostatic hypotension
Important ones (bolded):
Suicide attempt
Interactions:
Lab Test Results
None reported
Contraindications:
NOT FOR CHILDREN
Pts with hypokalemia
Recent acute MI
Nursing Considerations
Correct electrolyte disturbances before starting
drug
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