Study Guides (248,299)
Canada (121,468)
Psychology (531)
PSYC 280 (50)

Bio-Psych: Drug Effects on Pre and Postsynaptic.doc

2 Pages
Unlock Document

PSYC 280
Neil Watson

Sub-steps Drug Examples Three Major Drug Effects on PRESYNAPTIC Mechanisms A) Effects on Transmitter Production 1) Inhibition of Transmitter Synthesis Para-chlorophenylalanine inhibits tryptophan hydroxylase (enzyme), preventing synthesis of serotonin from its metabolic precursor 2) Blockade of Axonal Transport Cholchicine impairs maintenance of microtubules and blocks axonal transport; 3) Interference with the Storage of Reserpine blocks the packaging of transmitter Transmitters molecules within the vesicles, thereby allowing the transmitter to be broken down by enzymes B) Effects on Transmitter Release 1) Prevention of Synaptic Transmission Tetrodotoxin (puffer fis+) & local anaesthetics blocks voltage-gated Na channels and prevents nerve conduction (action potentials) 2) Alteration of Synaptic Transmitter Ca channel blockers (Verapamil) inhibit Release release of transmitters; Amphetamines stimulate release of catecholamine transmitters; black widow spider venom causes overrelease, and thus, depletion of Ach. 3) Alteration of Transmitter Release Caffeine competes with adenosine (an through Modulation of Presynaptic endogenous ligand, a neuromodulator) for Activity presynaptic receptors, thus preventing its
More Less

Related notes for PSYC 280

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.