PSYC 280 Study Guide - Tryptophan Hydroxylase, Latrodectus, Axoplasmic Transport

• School: Simon Fraser University
• Department: Psychology
• Course: PSYC 280
• Professor: Neil Watson

Document Summary

Inhibition of transmitter synthesis: blockade of axonal transport. Transmitters: effects on transmitter release, prevention of synaptic transmission, alteration of synaptic transmitter. Release: alteration of transmitter release through modulation of presynaptic. Inactivation of transmitter reuptake (blocking transporters, inhibiting enzyme degradation: blockade of transmitter degradation, effects on transmitter clearance. Two major drug effects on postsynaptic mechanisms: effects on transmitter receptors, blockade of receptors. Para-chlorophenylalanine inhibits tryptophan hydroxylase (enzyme), preventing synthesis of serotonin from its metabolic precursor. Cholchicine impairs maintenance of microtubules and blocks axonal transport; Reserpine blocks the packaging of transmitter molecules within the vesicles, thereby allowing the transmitter to be broken down by enzymes. Tetrodotoxin (puffer fish) & local anaesthetics blocks voltage-gated na+ channels and prevents nerve conduction (action potentials) Ca2+ channel blockers (verapamil) inhibit release of transmitters; amphetamines stimulate release of catecholamine transmitters; black widow spider venom causes overrelease, and thus, depletion of ach.