IMIN371 Study Guide - Midterm Guide: Cd19, Follicular Dendritic Cells, Phosphatidylinositol
16 Oct 2016
School
Department
Course
Professor
Document Summary
B cell antigen: a substance that binds an antibody (protein, carbohydrate, dna). Epitope: a portion of the antigen recognized by antibody. Polyclonal antisera: a collection of di erent antibodies from serum that recognize di erent epitopes of the same antigen. Monoclonal antibody (mab): antibody derived from a single b cell. Antibody variable regions: vh and vl - areas that bind antigen. Antibody constant regions: ch and cl - provide structure for the antibody and c-terminal constant regions of the heavy chain have e ector functions. The immunoglobulin motif/fold: a common motif in immune proteins, ~110 amino acids folded into two -sheets (each containing three or four antiparallel -strands) and stabilized by an intrachain disul de bond. Complementarity determining regions (cdrs)/hypervariable regions: portions of the variable regions of antibody molecules that contain the antibody-binding residues (loops in vh and vl). Fragment antigen binding (fab): the part of the antibody responsible for binding antigen.
