IMIN371 Study Guide - Final Guide: Immunoglobulin G, Allergy Test, Phagocytosis
16 Oct 2016
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Allergen-specific ige binds mast cells via fc ri and degranulate when ige cross-links at the surface. Mediators such as histamines cause inflammation (vasodilation, vascular permeability, smooth muscle contraction) Antibodies other than ige bind cell surface antigens and induce cell death. Adcc (antibody-dependent cell mediated cytotoxicity) by nk cells. Fc or c3b receptors bind and phagocytose the cell. Immune complexes are inefficiently cleared by phagocytes or complement following an adaptive immune response. Causes continual release of inflammatory mediators by mast cells, neutrophils, and macrophages as antibodies bind. Fcrs and continual complement fixation and production of c3a and. Immune complexes interact with platelets to form small clots. Angioedema (swelling of dermis, mucosa and underlying tissue) Antibodies against glomerular basement membrane kidney failure. Arthus reaction of generating large and extensive immune complex lattices immune complexes lodged in the skin. Immune complexes in the blood (fall out of solution in glomerulus can get stuck: massive systemic complement activation.
