ANSC 4470 Study Guide - Quiz Guide: Fructose-Bisphosphate Aldolase, Oxidative Phosphorylation, Caffeine

• School: University of Guelph
• Department: Animal Science
• Course: ANSC 4470
• Professor: John Cant

Document Summary

Glut are all related to each other geneically, carry out transportaion kineics, have common characterisics. Mutaions occurred in the original glucose transporter, creaing diferent km"s. Glut1 is found in most cells, has a km around physiological range. Glut2 looks ater blood glucose in the body, found in liver & kidney & pancreas, has a high km (very responsive to glucose) Glut3 is found in the brain, has a low km, at vmax most of the ime (will always uptake glucose, does not change its uptake) Glut4 is the main glucose transporter for muscle & adipose issue, responds to insulin: similar to glut1, changes in physiological range to blood glucose levels. Insulin simulates translocaion of glut4 onto plasma membrane. Glut1 works as a tetramer with one glucose binding site per glut1: atp binding closes intracellular cage & exposes addiional sugar binding site per glut1, 3d structure & its afect on the funcion of the glucose transporter.