BIOC 3560 Study Guide - Midterm Guide: Glucokinase, Phosphate, Acetyl-Coa
7 Mar 2016
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Document Summary
Pro required for its function: prosthetic group: a compound/cofactor that is permanently associated with a. Reversible modulation of pro function: pro are dynamic molecules, function is influenced by influence of other molecules, interactions can be very stable. Interactions can be transient and short lived: ligands are separate from prosthetic groups, pro-ligand interactions. Binding site: binding sites are complementary in size, shape, charge and hydrophobicicty, interactions are highly specific, pro can have more than 1 binding site. Binding of the enzyme, dihydrofolate reductase to its substrates demonstrates the complementary shapes of ligand and ligand binding sites in pro. Ligands are able to influence shape of pro and are not rigid poles. Induced fit is capacity of pro to interact and make cell function. Prescence and absence of substrate can influence shape of pro. This tendancy is reduced when iron is incorporated into heme: heme: a prosthetic group = protoporphyrin ix + fe2+
