BIOL 1090 Study Guide - Comprehensive Final Guide: Deoxyribonucleoside, Fragile X Syndrome, Amine
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1 Dec 2016
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Macromolecules are molecules containing a large number of atoms such as protein, nucleic acid or synthetic polymer. Nucleotides are composed of 3 generic things a a phosphate group, ve carbon structures, clclic nitrogen containing a compound called a base. In dna the sugar is 2-deoxyribose in rna the sugar is ribose. Four different bases are found in dna = adenine, guanine, thymine and cytosine. Rna also has four different bases= adenine guanine cytosine and uracil. Adenine and guanine are double ringed bases (purines) Thymine, cytosine and uracil are all single ringed bases called pyrimidines. Purine and pyrimidine nucleotides in polynucleotides are connected by phosphodiester bonds. Dna is double stranded and two of the strands are anti parallel. (exist as a double helix) One full rotation (360) = ~ 10 base pairs = 3. 4 nm (1nm=0. 001 ) Double helix structures is when two polynucleotide chains are coiled about one another in a spiral.
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QUESTION 1. Compared to eukaryotic genomes, only prokaryotic genomes:
A. contain DNA organized by histones. |
B. contain usually one, circular chromosome. |
C. contain plasmid DNA. |
D. have chromosomes contained in a nucleus. |
QUESTION 2. Azathioprine is a drug that may be prescribed to transplant recipients to reduce the chance of tissue rejection reactions. In its active state, it acts as a purine analogue, inhibiting DNA biosynthesis. This means that 6-mercaptopurine will be inserted in place of a purine containing nucleotides during DNA replication. Given this drug's mode of action, you would expect it to be incorporated into DNA in place of:
A. nucleotides containing guanine or cytosine. |
B. nucleotides containing adenine or thymine. |
C nucleotides containing adenine or guanine. |
D. nucleotides containing guanine nucleotide or uracil. |
QUESTION 3. RNA is distinguished from DNA because only RNA:
A. typically exists as a single-stranded molecule. |
B. has a 3' to 5' directionality. |
C. is composed of nucleotides that contain the sugar deoxyribose. |
D. is composed of nucleotides that contain the nitrogen bases T, C, G, and A. |
QUESTION 4. How are RNA nucleotides different from DNA nucleotides? To be marked correct, you'll need to select all true statements, as there may be more than one correct answer.
A. RNA nucleotides do not contain thymine. |
B. RNA nucleotides use the sugar ribose, while DNA nucleotides do not. |
C. RNA nucleotides lack phosphate. |
D. RNA nucleotides incorporate pyrimidine nitrogen bases, while DNA nucleotides only incorporate purine nitrogen bases. |