BIOM 3090 Study Guide - Final Guide: Coronary Circulation, Angina Pectoris, Chest Pain

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Bettina Kalisch

Document Summary

Heart can control its own output based on o2 demand. Exercise work load o2 demand. Dilation of coronary arteries o2 supply. Insufficient coronary bf o2 deprivation muscle strength acute hf. Angina = o2 deprivation and muscle pain. Chest pain caused by imbalance between o2 supply and demand. (cid:862)irreversible(cid:863) obstruction of coronary arteries (blockage prevents dilation) Spasm of part of coronary vessel (often at site of plaque) Bv and venous tone (preload, higher pressure on venous side will restrict cardiac filling, need for o2) Aims to restore balance between oxygen supply and demand. O2 demand by hr, co, pvr. O2 supply by coronary blood flow. Oral: metabolized by liver, several minutes onset, 6-8h duration. Sublingual: 1-3 minute onset (good for quick relief) but 10-20min duration. Mechanism: nitrate groups converted to no cgmp relax smooth muscle cells vasodilation. Also affects sm in other tissues (bronchioles) Effect: venous return, pvr, dilates coronary arteries. Toxicity: hypotension, tachycardia (reflex sns activity) and headaches.