PHAR 301 Lecture Notes - Lecture 6: Hmg-Coa Reductase, Coronary Artery Disease, Myocardial Infarction
1 Feb 2016
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Myocardial ischemia: failure to meet the demands of the oxygen supply of the heart - there is an imbalance. Drugs that are used to treat symptoms of myocardial ischaemia are the same as drugs used to treat hypertension (symptomatic drugs) cardiovascular problems (prophylactic) Drugs that are given to prevent myocardial ischaemia will reduce the chances of having. Myocardial infarction: pharmacological intervention o o o o o. There are many factors that determine if that balance is met coronary circulation. Cannot get more oxygen into the blood o. Therefore, redistribution of regional myocardial flow is of major importance. Angina pectoris (chest pain) o o o o. Manifests in different forms: o o o o. Pain is due to accumulation of metabolites in muscle tissue. Stable angina - atherosclerotic block of coronary artery. Myocardial infarction - heart attack, death of tissue o. Deposition of fatty substances, especially cholesterol or fatty acids in arteries. May occur in patients with or without atherosclerosis o.
