PHPY 304 Study Guide - Midterm Guide: Cytochrome P450, Enterohepatic Circulation, Monoamine Oxidase

• School: U of S
• Department: Physiology and Pharmacology
• Course: PHPY 304
• Professor: Desai Kash

Document Summary

Steve hall thu oct 20 05:31:08 pdt 2016. The purpose of drug metabolism is to convert a nonpolar lipid molecule so it cannot be reabsorbed t/f. Brain tumor tissue capillaries do not have tight jxns t/f. Blood-brain barrier has high enzyme activity for many compounds t/f. Oral dopamine (nt) is useful to treat parkinson"s t/f. Normal brain capillaries allow polar molecules to enter the brain t/f. Normally tyramine is metabolized by the enzyme monoamine oxidase t/f. Tyramine in the circulation can cause low blood pressure. Dietary tyramine is rapidly excreted by the kidneys after absorption and is not harmful. Tyramine is a parasympathomimetic compound found in certain foods. An acid is a proton donor and its protonated form is charged and better absorbed. Cytochrome p450 enzymes attach another group to drug molecule to make it polar. Cytochrome p450 enzymes are located in the er of the cell. Cyp enzymes can be induced, inhibited, or undergo mutation.