KIN404 Study Guide - Midterm Guide: Thyrotropin-Releasing Hormone, Cannabinoid Receptor Type 1, Vagus Nerve

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Released by the stomach and increases hunger and decreases energy expenditure, anabolic pathway: ghsr- receptor, 1. Lkb- which is basically through decreases in atp and more adp: influx in calcium concentrations through camkk- when ghrelin binds to neurons, it signals increases in intracellular calcium and drives up hunger, 1. Catabolic hormone that has the same effect of insulin and leptin: activates pomc, 1. Levels are proportionate to body fat content: promotes weight loss, blocking the actions of these signals increases food intake and body. Para ventricular nucleus - pvn function of enteroendocrine cells. Beta endorphins only leptin and insulin satisfy this: 1. Houses the 2nd order catabolic neurons and peptides, such as trh (thyroid releasing hormone) and crh (corticotropin releasing hormone): 1. Gi tract releases cck, pyy, pp or adipose tissue releases leptin: vagus nerve gets activated, pomc/alpha-msh gets released in the arc. Cck- cholecystokinin: npy/agrp gets inhibited due to mc3 receptor sensing alpha-msh.

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