KIN404 Study Guide - Midterm Guide: Brown Adipose Tissue, Uncoupling Protein, Serca

• School: University of Waterloo
• Department: Kinesiology
• Course: KIN404
• Professor: Russ Tupling

Document Summary

What is the major contributor to body mass in the human body: 1. leptin receptors are located on skeletal muscle, directly stimulating. Increase vo2: leptin ob/ob mice when given leptin exogenously undergo thermogenesis. - increase vo2, leptin db/db mice (lacking receptors) do not under go thermogenesis when given leptin exogenously. Where is most of the sarcolipin found: decrease thermogenesis, decrease vo2, 1. diet induced obesity, insulin resistance. this is because ucp-3 is an uncoupling protein, more uncoupling will lead to more energy expenditure, 1. Leptin/crh released: activation of pomc, activation of pvn, sns released norepinephrine. What increases serca efficiency: b3-adrenergic receptor on surface of tissue get activated. What does an ampk agonist do to leptin signalling: developed glucose intolerance and hyperleptinemia. Effect of fatty acid chain length on serca calcium transport efficiency: highest glucose levels, lower food intake , higher sns activation.