ANP 1107 Study Guide - Final Guide: Sertoli Cell, Folliculogenesis, Leydig Cell

• School: University of Ottawa
• Department: Anatomy and Physiology
• Course: ANP 1107
• Professor: Jackie Carnegie

Document Summary

Producion of perm and semen and their propulsion into the external environment: spermatogenesis: No cell division in this process (transformaional, not proliferaive) Muscular (dartos wrinkles scrotum, cremaster elevates tesicles) Vascular (pampiniform venous plexus cools arterial blood) Direct regulators of the process: secrete growth factors that simulate proliferaion and difereniaion (in response to testosterone and. Fsh: release androgen-binding protein in response to fsh. Testosterone promotes sperm development: tight juncions form blood-tesis barrier. Anything that comes out of the blood has to go through the sertoli cells to get to the sperm (example: microorganisms: secretes inhibin (negaive feedback) To make sure that gonadotropins don"t get too high. Two primary ones in gametogenesis: luteinizing hormone (lh, follicle-simulaing hormone (fsh) Note the separaion of androgen producion and perm development. Release simulated by gnrh (gonadotropin releasing hormone) from hypothalamus. Testosterone: simulates release of growth factors from sertoli cells -> simulates spermatogenesis. Simulates sertoli cells to express androgen-binding protein (abp) -> increases local testosterone concentraions.