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BIO1140 summary notes.doc

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Department
Biology
Course Code
BIO1140
Professor
A L L

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Description
BIO1140CELLBIOLOGYSUMMARYNOTESTOPIC1CELLSLIFEANDSIZEOccamsRazororThePrincipleofParsimonyItisvaintodowithmorewhatcanbedonewithlessWilliamofOccamc12851349StudyallofChapter1plusA1toA6NotPhaseContrastYetTHREEFUNDAMENTALPROPOSITIONSThefundamentalunitoflifeisthecellCellsaresmallandarethusgovernedbyforceswhicharelargelyforeigntousAllextantcellsevolvedfromasingletypeofprimordialancestorInthislectureIwanttohelpyougetafeelforhowsmallcellsareandperhapsmoreimportantlyforsomeoftheconsequencesoftheirminutenessForexamplehumansarelargeorganismsandsowearedominatedbytheforceofgravityConverselysmallorganismsandcellsareinfluencedprimarilybydifferentforcessuchasviscosityandsurfacetensionTouscellsandsmallorganismsliveinaverystrangeworldButbeforewecantalkaboutthesizeofcellsyoumustfirstunderstandtheunitsofmeasurementusedinthestudyofcellsandmolecularbiology6910Theunitsoflinearmeasuremostoftenusedtodescribecellstructuresaremicrometersmicronorm10mandnanometersnm10mThengstrom10misoftenusedbymolecularbiologistsforatomicdimensionsalthoughthisdimensionisnolongerformallyacceptedinmetricnomenclatureThelimitofresolutionbestpossibleresolutionforamicroscopethatusesvisiblelightisabout03M300nMinairand02M200nMwithanoilimmersionlensSaycouldyouexplainwhythedifferenceexistsDontaskmelookitupinatextSomeexamplesofdimensionsofcellsandcellcomponentstheseareballparkfigures1ahydrogenHatom01nMor12smallmolecules04to08nM3basiclipidmolecule2to4nM4typicalglobularproteinmyoglobin45nmx35nmx25nm5highlyelongatedproteinscollagenmyosinover100nminlength6DNA2nminwidthitslengthvariestremendously7largemolecularcomplexesribosomesmicrotubulesmicrofilaments525nmdiameter8nucleiabout10mdiameter9mitochondriaabout2minlength10bacteria1to5minlength11eukaryoticcells10to30minlengthTopicshierarchicalreductionismtheCellTheoryincludingthethreebasictenetstheLawofBiogenesisandatleast10characteristicsoflifeNamestoknowjustknow19thCenturyRobertHookefirsttoseecellsMatthiasSchleiden1838andTheodorSchwann1839thefirsttwolawsoftheCellTheoryRudolfVirchow1855theBiogeneticLawOhandofcourseHenriettaLackswhocontributedthefirsthumancellsfromamalignanttumortobeartificiallyculturedgivingrisetotheveryfamouslineofhumanculturecellscalledHeLacellsYoushouldknowthisbecauseyouwillseethenameHeLaagreatmanytimesasyoustudythelifesciencesThenofcoursethereisGordieHowethegreatesthockeyplayereverAssignmentFortenminutespretendyouareasmallmoleculeletssayanaminoacidofabout100DaandtrytothinkwhatforceswillbeactingonyouandhowyouwillbehaveasyougoaboutyourdailyroutineTrustmeifyoudotodaywillbeunlikeanydayyouhaveexperiencedpreviously
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