TOPIC 7 ANTIBIOTICS.docx

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Department
Biopharmaceutical sciences
Course
BPS1101
Professor
Mary Theresa Howard
Semester
Winter

Description
BPS1101TOPIC7Antibiotics1900maincausesofdeathpneumoniatuberculosisinfluenza2004maincausesofdeathheartdiseasecancerstrokelowerrespiratoryinfectiontrafficaccidentsMaternalmortalityratesdecreasedbecauseofpenicillinSurgerysurvivalratewaslessthan30AgostinoBassishowedmicrobescauseddiseasesAtharvaVedaidentifieslivinganimalsascausingthediseaseLouisPasteurdevelopspasteurizationin1864andfoundoutspoiledfoodcausedbybacteriacauseddiseasesListeradiscipleofPasteurdevelopsantisepsisTrypanredselectivelycolorstrypanosomesoReplacedwithAsarsenictomakedyemorepoisonousSalvarsan606wastheFIRSTeverantibioticdiscoveredoTreatedsyphilisthegreatpoxoCompoundwasntverydruglikeoRequiredawholeyearoftreatmentandwassotoxicthatyoucouldonlyinjectitonceaweekoPainfulanddangeroustoinjectoCouldnecrotizethetissueifinjectedintomusclemassProntosilonlyeffectiveinvivobecauseitwasaprodrugandgetsmetabolizedintosulfanilamideSulfanilamidebecomesfirstsulfacommercialantibioticdrugin1932oInhibitbacteriagrowthandstopsinfect
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