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Lecture and Notes 1 - Microbiology.docx
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Department
Health Sciences
Course
HSS1100
Professor
Franco Pagotto
Semester
Winter

Description
Microbiology Immunology: study of our protection from foreign macromolecules or invading  organisms and our responses to them Microorganism: invisible to the naked eye; most harmless and useful a) Viruses  • Consists of nucleic acid (RNA or DNA) • Surrounded by protein shell (caspid) • Attach, inject DNA, highjack synthetic process in living cell of replication b) Bacteria • Prokaryotes (unicellular) • Both DNA and RNA • Rigid cell wall • Circular chromosome (genetic matter) • Reproduce through binary fission * Benefits: spoil food (visible warning), biotechnology, biomediation c) Eukaryotes • Unicellular and multicellular animals and plants • Genetic material in nucleus Transient Bacterial Flora: found in specific location; result of displacement of resident  bacterial flora (G­I Tract) • Protection from invasive bacteria • Metabolism – synthesize Vitamin K • Immune stimulation Phagocytosis: macrophages and neutrophils ingest bacteria and kill • Attach and form vacuole around bacteria (some protect with polysaccride capsule) • Body produce antibodies for capsule •  Opsonization    – alter surface of capsule permitting phagocytosis Complement: proteins that resist bacterial infection Bacteraemia: bacteria in blood Speticeamia: blood poisoning Infection: penetration of microorganism that multiplies producing apparent or inapparent  changes Colonization: establishment and mult
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