HSS 1100 Midterm: HSS 1100 Midterm 2 notes

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 1100
• Professor: William Yan

Document Summary

Stable, resistant to heat, drying, uv and disinfectants. Humans are exposed through contact with animals or soil. Used in bio-terrorism and warfare: bacillus anthracis exotoxin. Encoded on pxo1 plasmid (tiny dna, code for proteins) Plasmid contains virulence factors- 37c, increased co2 and serum proteins. Composed of- edema factor (ef), protective antigen (pa), lethal factor (lf) (together lethal, separately are not toxic) Pxo2 plasmid encodes capsule genes (both required for virulence) Prevention and treatment: rapid, antibiotics- penicillin, ciprofloxacin, vaccine against pa protein is available. Enterotoxin responsible for illness: heat labile- nausea, abdominal pain, diarrhea (12-24 hours, heat stable- severe nausea and vomiting, short incubation. Anaerobic (different from other spore-forming) deep in soil. Rapidly fatal food poisoning from lethal neurotoxin. Neurotoxin blocks ach release in autonomic system, flaccid muscle paralysis: afebrile, bilateral cranial nerve palsies, double vision, trouble swallowing, muscle weakness, respiratory paralysis death, treatment- antitoxin and respiratory assistance. Smoked fish, improperly canned vegetables (proper cooking destroys pores)