BIO206H5 Study Guide - Final Guide: Prokaryotic Small Ribosomal Subunit, World Federation Of Trade Unions, Transfer Rna

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18 Feb 2016
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Bio206 tut0113: the stop codons for translation are uag ( amber ), uaa ( ochre ), and uga ( opal ). The codons for the amino acids tyrosine (uau and uac), cysteine (ugu and ugc), and tryptophan (ugg) if altered would most likely lead to premature termination of translation. The stop codons are very similar to the codons for these amino acids, with the exception of the nitrogenous base in the 3rd position. If any the amino acid codons were mutated, and the last nitrogenous base was altered, the codons would signal translation termination instead of the appropriate amino acid. Because the anticodon sequence is mutated, the trna will not be able to recognize the correct codon in the mrna that determined the appropriate amino acid. This could be detrimental as we see in the -hemoglobin example where a single amino acid change can alter the entire shape of the red blood cell.

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