BIO315H5 Study Guide - Final Guide: Cyclic Adenosine Monophosphate, Phagocytosis, Glycoprotein
Document Summary
Proteins can travel w/out having to cross a cell membrane through means of lumen topology being equal w/ other internal environment of cell compartments & cell exterior. Secretory pathway: leading out form er to golgi apparatus & cell surface, with side route to lysosomes. Endocytic pathway leads inward from plasma membrane. Molecular mechanism of membrane transport & maintainence of. (ow can each compartment maintain it(cid:495)s special identity: composition of enclosing membrane s/as molecular markers on the mem surface. So vesicles fuse w/ only correct target compartment. Each clathrin subunit consists of 3 large & 3 small polypeptide chains that together form a tiskelion. These form on cytosolic side of membrane as pits: adaptor proteins select cargo into clathrin-coated vesicles, adaptor proteins form inner layer of clathrin-c vesicles. Ap2 rearranges so binding sites for cargo receptors being exposed. Ap2 tightly binding to cargo receptors induces curvature.
