BIO315H5 Study Guide - Midterm Guide: Alpha Helix, Coiled Coil, Protein Folding
Document Summary
B- pleated sheets, 5-8 residues long, h bonds between carbonyl group and amino group of backbone. Zinc finger motif made of 1 alpha, 2 beta, has either his or cys bound to a zinc, important in dna & rna binding protein. 10 anti parallel beta strands connected by hairpins. Helix loop helix asp and glu bound to ca+ (found in ca+ binding sites: phosphorylation covalently bonds an phosphate group (po3) to a oh in serine, threonine, tyrosine (kinase). Function: activate/deactivate proteins, changes shape reverse = phosphatise ::: hydroxylation adds a oh group. Function: in animals: uses absorbic acid (vitamin c) to assemble collagen, lack of vit c = scurvy. :::: lipidation: adds a fatty acid to the protein. Function: helps anchor down membrane proteins, essential in cell membrane signalling events. ::: carboxylation: allows binding of inorganic molecules ::::: acetylation: adds an acetate group to amino acids.
