BIOC14H3 Study Guide - Chemotherapy, Human Genome Project, Prostate
1 May 2014
School
Department
Course
Professor
Document Summary
Video 1: epigenetics = original paradigm from twin studies (monozigotic, di), share 50% of segregating polymorphisms, 99. 5% dna identical. Easy to identify association between 2 things (like stress and depression), hard to see if it is causal (depression stress or stress depression) Only the non-shared environment is important: genetic problems. Unexplained heritability: gwas may identify thousands of genomes, convert information into heritability estimates (heritability of autism is 90, bipolar disorder is 80%, schiz is 70%, gwas can only explain 70% of that heritability. Despite all those differences, we still focus on dna seq variation because. Histones and dna seq can be chemically modified (methylated, phosphorylated, etc): he focuses on dna modification methylation of cytosines. There are 4 types of modification hydroxyl methyl cytosines, carboxy cytosines, formyl cytosines. 2 identical genes on slide one has modified cytosines, other has methylated cytosines.
