NROC61H3 Study Guide - Opioid Receptor, Anxiogenic, Narcolepsy
Document Summary
Lec06 lecture overview: what do we associate with reward, neurochemical substrates of self-administration, dopamine function in reward, hedonic orofacial reactions to reward. Ic ss: drug self adminstration, animals will voluntarily self administer drugs abused by humans accidental beginnings of icss. 2. rats will lever press at a high rate for electrical stimulation of certain area of the brain: will do this at the cost of eating and drinking. 3. led to beginning of a way of mapping circuitries in the brain responsible for reward. Icss positive sites: medial forebrain bundle important in reward for self stimulation, stimulation of limbic areas did not induce a high response rate of icss. Icss punishment sites: periventricular system, a lot of hypothalamic nuclei other hot spots, do not need to memorize. 3. tongue protrusions / lip smacking associated with sweet hedonic reactions: 6-ohda lesions did not have any effects on hedonic responses to reward vs aversive substance dopamine and wanting.
