BCH210H1- Final Exam Guide - Comprehensive Notes for the exam ( 115 pages long!)

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Gpa has transmembrane helixes, but chou fasman predicts its beta strands. This is because of the large h(cid:455)d(cid:396)opho(cid:271)i(cid:272) (cid:396)esidues i(cid:374) gpa, a(cid:374)d this is(cid:374)"t p(cid:396)edi(cid:272)ted i(cid:374) the (cid:272)hou fas(cid:373)a(cid:374). Also (cid:271)e(cid:272)ause (cid:272)hou fas(cid:373)a(cid:374) o(cid:374)l(cid:455) p(cid:396)edi(cid:272)ts solu(cid:271)le p(cid:396)otei(cid:374)s, the(cid:455) do(cid:374)"t appl(cid:455) to (cid:373)embrane proteins. The alpha helix structure shields polar atoms of the backbone. High hydrophobicity of amino acids in gpa overcomes the chou fasman propensities. The membrane is 30a thick / each aa is 1. 5a = 20aa. They are linear because it minimizes membrane disruption. The polar groups of the backbone are shielded in h-bonding. The oceans are pink because they are very salty, so the high salt decreases the o2 concentration in the water, and one bacterium that grow in these conditions produce bacteriorhodopsin which makes it pink. The retinal group in this molecule is covalently linked, and the retinal group can give off colours.