HMB200H1 Study Guide - Final Guide: Transcranial Magnetic Stimulation, Motor Neuron, Sensory Neuron
Document Summary
Stimulate one neuron and record response in the downstream neuron: stimulate perforant path (pp) which projects to the dendrites of dendate gyrus (dg). Record epsps in pp neuron groups and the population spikes of the dg. Easily reversed, short lasting: dehabituation: if the pattern is broken by another stimulus or the stimuli stop/become too far apart the effect dies down. It can also occur when a small stimulus is paired with a larger one (heterosynaptic): heterosynaptic: a facilitatory interneuron recives the "shocking" input and releases 5- Ampa receptors trigger na/k channel openning and causes depolarization. nmda are usually blocked by mg, but it is expelled out when the cell depolarizes allow for further ca influx. Can be associated, where stimulation of similar pathways may cause a net ltp when they wouldn"t alone: associative: properly timed stimulation of one neuron may cause slight depolarization in a nearby neuron and trigger ltp as well.
