IMM250H1 Study Guide - Innate Immune System, Lectin, Neutrophil

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3 Feb 2013
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Innate Immunity II
Acute Phase Response
Δ in blood in early phase of immune response
Involves protein and cellular elements
1st macrophages/neutrophils to arrive release
cytokines
Tumour necrosis factor α TNFα
Interleukin 1 and 6 (IL-1, IL-6)
o Causes body temperature,
inflammation
Fibrinogen: starts clotting cascade
Clots bvs downstream of injury
so infection cannot spread
Problems: flow backup
= inflammation, swelling
loosen bv endothelial lining
blood gets into ECM
o Allows immune cells to move easily
between cells to kill pathogens
Complement: group of blood proteins that recognize and destroy microbes
Overview of the complement cascade
Overview of the main components
and effector actions of complement
In innate immune system:
Alternative pathway
o Proteins:
C3
Factor B
Factor D
C5
Unique to
alternative
pathway
C6
C7
C8
C9
Common to all
pathways
* See Fig 2.26 for list of fxns
for all compliment proteins
Lectin pathway
In adaptive immune system: classical / humoral pathway
Antibodies recognize, compliment (innate) destroys
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