Study notes for midterm

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Molecular Genetics and Microbiology
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William Navarre

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27 DNA mutations and repair Mutationheritable change in base sequence of genomelead to change in phenotype Base substitution during replication Base changes from inherent chemical instability of the bases or of the glycosidic bond Alterations resulting from action of other chemicals and environmental agents including oxygen ultraviolet light nitrites Types of alterations of DNA molecules Missing basesIncorrect base in one strand that cannot form hydrogen bonds with the corresponding base in the other strand Altered basesSingle strand breaks Double strand breaksCrosslinking of two DNA strands Point mutations Silentno change in amino acid Neutralchange in amino acid but functionally equivalent Missensedifferent amino acid Nonsenseforms stop codon Frameshiftall downstream codons out of registerPromoterchanges promoter recogn
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