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Department
Molecular Genetics and Microbiology
Course
MGY377H1
Professor
William Navarre
Semester
Fall

Description
34 ANTIBIOTICSANTIBACTERIAL CHEMOTHERAPY AND DRUG RESISTANCEAntibioticsubstance produced by microorganism or a similar product produced wholly or partially by chemical synthesis and in low concentrationinhibits growth of or kills microorganism EhrlichNobel laureate Created concept of drug Discovers Salvarsantoxiccontains arsenicbut more toxic to syphilis than people DomagkNobel laureateDiscover protosil an antibiotico Which is metabolized to active form by animal cellso Into sulphanilamide which inhibits growth by interfereing with the synthesis of folic acido Sulphanilamide is competitive inhibitor of dihydopteroate synthetaseo So bacteria no longer can make the dihydropteroate necessary for folic acido Humans still obtain sufficient folic acid from their diet and therefore are not harmed by sulphanilamide FlemingNobel laureateDiscovered penicillin What makes a good antibioticSelective toxicityo Against target pathogen but not agai
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