PCL302H1 Study Guide - Final Guide: Molecular Switch, Chemotherapy, Renal Blood Flow

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Course coordinator: dr. jane mitchell: phone: 416-978-0841, email: jane. mitchell@utoronto. ca, office hours: tues. 11-12pm or by apt. Suggested textbook: principles of medical pharmacology 7th ed. Timeline: from [1910s receptor theory] to [1970s purified proteins, paul ehrlich. Receptive substance now receptor: detecting receptors. Example of a more efficient drug: asa (aspirin) celecoxib (celebrex: analgesic and anti-inflammatory, asa has gastric discomfort and anti-coagulant side-effects because it targeted cox1 more than cox2, celecoxib is more selective for cox2. Types of drug receptors: endogenous receptors for ligands (hormones, neurotransmitters, cytokines) beta blockers, enzymes asa, nucleotides cysplatin, water laxatives. Quantitative description of drug action assumes: drug binds to receptor reversibly and with high affinity, effect is proportional to number of receptors occupied. Kd is the [drug] required for 50% of receptor occupancy. Radioactive labelling (hot drug) in various concentrations. Measure radioactivity (bound drug) in a scintillation counter. Hot drug is binding to both receptors and nsbs: measure non-specific binding.

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