PHC340Y1 Study Guide - Comprehensive Final Guide: Bioavailability, Microcrystalline Cellulose, Standard Deviation
1 Dec 2016
School
Course
Professor
Document Summary
The stability of a drug influences how it is formulated. In this lab, we explored the stability of acetylsalicylic acid in liquid solution and suspension. This was performed with a kinetic study of the drugs hydrolysis. Even at ph 4, asa exhibits considerable aqueous degradation and the hypothetical room temperature shelf life using our calculated parameters ended up being roughly 9 days. The suspended form fared no better, having a low half life as well. It was concluded that these formulations of asa are not suitable for industrial purposes and that new formulation should be explored if we are to be serious about coming up with a liquid asa dose. In pharmaceutical formulations, it is important to assess the stability of a compound so that an estimate of its shelf life can be reported with the drug. This involves studying how the drug decomposes and the rate at which the decomposition occurs.
