PSY396H1 Study Guide - Final Guide: Choline Acetyltransferase, Nicotine Replacement Therapy, Nicotinic Acetylcholine Receptor
Document Summary
Choline + acetyl coa [choline acetyltransferase] acetylcholine + coa. Ach found in cholinergic neurons, used in the brain, used in muscles. Acetyl coenzyme a acetyl coa, metabolite from sugar and fat. Choline is from dietary fat (fish, meat) and the liver. Vesicular ach transporters (vacht) moves ach into synaptic vesicles. Acetylcholinesterase (ache) breaks down ach choline + acetic acid can be blocked by vesamicol to reduce ach release found in the presynaptic and postsynaptic membrane. Choline transporter move choline + acetate back into presynapse can be blocked by hc-3. Acetylcholine roles: muscle movement ach found at neuromuscular junctions. Autonomic nervous system sympathetic & parasympathetic response, target muscles, organs. Cns preganglionic neuron ach to parasympathetic ganglionic neuron ach to target organ. Cns preganglionic neuron ach to sympathetic ganglionic neuron ne to target organ. Basal forebrain cholinergic system origin of ach innervation of cerebrum, hippocampus, limbic areas interneurons in the striatum, regulate movement.
