MICR 303 Study Guide - Midterm Guide: Human Papillomavirus Infection, Interleukin 4, Cytochrome C

• School: University of Victoria
• Department: Microbiology
• Course: MICR 303
• Professor: Catherine Bachewich

Document Summary

Adaptive immunity: roles and application of antibodies (general) Def: substance recognized by adaptive immune system includes: proteins, lps, metals, penicillin, organ chemicals (poison ivy) Epitope: portion of antigen recognized by antibody. Hapten: small molecule that illicit immune response when coupled with a large protein ex: vitamin k: immunoglobulins. Membrane bound molecule comprising bcr that recognizes antigen. Is secreted form from of b cells (antibody) -> ex: igx. Affinity: single antigen binding site + antigen strength: general structure of antibody. 4 polypeptide chains -> differences n carboy terminus of heavy chain will give different ig classes (gamed) Variable and constant regions -> heavy and light have bother. Variable region is responsible for variable antigen binding (amino acids = diverse) Constant will determine effector function, the fc receptor will bind constant regions. Cleavage into fragments -> cleaved by proteolytic enzyme ex: papain -> makes fab (fragments antigen binding) and 1 fc (fragment crystallizable) ex: pepsin -> makes f(ab")2 and pfc".