Biochemistry 2280A Study Guide - Ketone Bodies, Triglyceride, Acetyl-Coa

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Christopher Brandl

Document Summary

Acetyl-coa part 2: fatty acids, ketone bodies, and biosynthesis. By the end of this topic, you should be able to: Carbohydrates are not the only source of acetyl-coa for the citric acid cycle. Fatty acids from stored triacylglycerol or from the diet can be degraded and oxidized to acetyl-coa. When energy is needed from fat storage, lipases in adipocytes degrade triacylglycerol into glycerol and three fatty acids. The released fatty acids enter the bloodstream and are used as fuel in other cells, such as skeletal muscle, heart, and liver. The released glycerol is a substrate for gluconeogenesis. In a cell that is using fatty acids for fuel, specific transporters move fatty acid from the blood into the cytosol. Then, the fatty acid is activated with coa in the cytosol in a reaction that is driven by hydrolysis of atp to amp and ppi. The resulting acyl-coa is transported into the mitochondrial matrix.