Biochemistry 2280A Study Guide - Final Guide: Nuclear Matrix, Dna Mismatch Repair, Pyrophosphate

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Explain the chemical structure of nucleic acid polymers, without memorizing the structures of the nitrogenous bases. Dna is a linear polymer composed of deoxyribonucleotide monomers: acts as a long-term repository for hereditary information. Rna is a linear polymer composed of ribonucleotide monomers. Each monomer composed of 3 parts: monosaccharide, nitrogenous base, and phosphate. Deo(cid:454)(cid:455)ri(cid:271)o(cid:374)u(cid:272)leotides (cid:272)o(cid:374)tai(cid:374) deo(cid:454)(cid:455)ri(cid:271)ose (cid:894)like ri(cid:271)ose, e(cid:454)(cid:272)ept that c(cid:1006)" (cid:271)ears (cid:1006) h ato(cid:373)s, i(cid:374)stead of (cid:1005) h and one hydroxyl) Two types of nitrogenous base: purines and pyrimidines: all purines/pyrimidines are planar and hydrophobic, 2 purines in dna/rna are adenine and guanine, 3 pyrimidines are cytosine, thymine, and uracil. Uracil is identical to thymine except that uracil lacks the methyl group: purines have 2 rings, pyrimidines have only 1 ring. Describe b-dna and the higher order structures formed by rna, and the important forces that stabilize these structures.

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