Biochemistry 3381A Study Guide - Quiz Guide: Human Herpesvirus 6, Lytic Cycle, Dna Virus
20 May 2020
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Prevent prr recognition thus signalling > activate innate immune mechanisms: induce antiviral state, chemokines recruit leukocytes , allow adaptive response launch upregulate co-stimulatory molecule expression sentinel cells, cytokine / direct pamp induction. Non-integrating dsdna viruses convert to circular episome e. g. herpesviruses: e. g. If itegrated germline cell every cell of offspring could potentially reactivate in any: found in 1% humans inherited chromsosomally inherited hhv- Simplest lytic viruses > lysis one form of cytopathic effect (easy to monitor) when induce shut off of host translation, dna virus and non-enveloped rna viruses tend to be lytic. Enveloped virus insert needed viral proteins into membrane so have them when they bud. Promote cell fusion: spread without release of free virions protect from immune system e. g. measles. Alter host: downregulate those that virus binds flu na remove sa prevent reinfection and allow dissemination, downregulate mhci evade cd8 cytotoxicity.
