Biochemistry 3381A Study Guide - Quiz Guide: Bone Morphogenetic Protein, Thanatophoric Dysplasia, Signal Transduction
27 May 2020
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The majority of inducers are proteins that work as paracrine factors. Many of these factors can be grouped in one of four major families (based on the structure) Transforming growth factor (tgf- ) superfamily the receptor tyrosine kinase (rtk); a typical for paracrine factors (e. g. fgf) A complex signal cascade links the receptor to transcription factors. (involved e. g. in the development of neural crest cells: mutations in signaling pathways often are fatal. Many cancerous tumors are caused by mutations of ras. Mutation of fgf receptor 3 causes thanatophoric dysplasia (newborns die because breathing is not possible) It contains the basis of the fly"s body plan: wnt signal transduction: the canonical pathway (involved e. g. in muscle induction, midbrain development or limb polarity) Additional (noncanonical) pathways are known leading to changes in the cytoskeleton or ca2+ release signal transduction pathways which begin with proteins that pass signals into the cell through the cell surface protein.
