Biology 2382B Study Guide - Midterm Guide: Cytochalasin, Microtubule Organizing Center, Treadmilling
5 Feb 2015
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Dr. damjanovski microtubules intricate network of protein filaments that extend throughout the cytoplasm. Microtubules (25 nm), intermediate filaments (10 nm), and microfilaments (7-9 nm) functions often require energy (scaffolding, positioning, moving, anchoring, generating force, etc) Microtubule disrupting drugs: tubulin, smooth edges are formed (polymerization) tubulin, frayed edges are formed (depolymerization: colchicine, taxol or colcemid depolymerizes stabilizes and kills fast dividing cells. Microtubule associated proteins (maps): bundle and stabilize microtubules can be phosphorylated to promote disassembly contain a microtubule binding domain and an acidic projection domain length of projection domain affects density of bundle. +tips well as act as attachment sites for anchoring. Microtubule half-life very short, indicating lots of movement kinetochore proteins allow microtubules to bind to centromere region of chromosomes. Microtubules are bound past the (+), and the (+) is free inside kinetochore protein. G-actin first nucleates slowly and then polymerization follows quickly.
