Biology 2382B Study Guide - Final Guide: Fibronectin, Facilitated Diffusion, Alpha Helix
8 Apr 2016
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Each monomer (alpha/beta) is 4nm and 50kda (dimer = 8nm) Two types cytoplasmic (most, ex axons) and e(cilia and flagella) Gamma tubulin and other proteins form gamma ring complex which nucleates polymerization. Provides lateral cohesion at + end (smooth) allowing polymerization, gdp at end causes fraying (lateral cohesion which sticks tog and with gtp this is greater) Don"t play role in growth, proteins around it do. Kinesin (+ end motor protein) exocytosis, anterograde. Dyenine (- end motor protein) endocytosis, retrograde. Map2 and tau: bind to mts and space them (map2 = more space) Eb1: binds at + end, stabilizes but also moves things to + end (cargo), moves along seam, could anchor mt. Slatherin: facilitates depolymerization that probably involves gto hydrolysis (phosphorylation inactivates) Heavy chains have atpase activity, head of heavy chain binds mts. 1: 2 heavy chains, 2 light chains (variable) 5: 4 heavy chains, bipolar (both ends same), mts are the cargo, mt sliding.
