Biology 2581B Study Guide - Quiz Guide: Tumor Suppressor Gene, Benzidine, Cervical Cancer
2 May 2020
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2-naphthylamine (benzidine) in rubber industry metabolised to active form in liver. Benzidine binds to dna, prevents proper dna division causes mistakes which accumulates cancer. Dna damage and breaks causes by uv light. Generating cross-links between the two strands of double helix. Causing breaks in one or both dna strands. Smoking (lungs), alcohol (month, liver) and poor diet. Mechanisms involving infectious agents causes 15% of cases (not directly) Hpv and chlamydia trachomatis causes cervical cancer. Hepatitis b (causes oncogenic virus), liver cancer and hepatitis c causes liver cancer. Uvb is the main causes of sunburn (superficial layer damage). Plays a key role in the development of skin cancer and photo-aging. Uva is a tanning ray that causes cumulative damage (basal layer damage) Increases squamous and basal carcinomas and melanomas. Activation of oncogenes and inactivation of tumour suppressor genes critical steps in tumour initiation and progression. The development of cancer is a multistep process in which normal cells gradually progress to malignancy.
