Biology 2581B Study Guide - Quiz Guide: Inner Mitochondrial Membrane, Acetyl-Coa, Pyruvate Dehydrogenase

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Mitochondria have two membranes: outer mitochondrial membrane: permeable for ions and small molecules. The intermembrane space therefore has the same ionic composition as the cytoplasm. Inner mitochondrial membrane: diffusion barrier to ions and small molecules. This membrane contains cristae (folds) containing proteins of the electron-transport chain and atp synthase. The mitochondrial matrix differs greatly in ionic composition from the intermembrane space. Pyruvate (derived from glucose, glycolysis) and fatty acids (derived from fats, beta oxidation) enter the mitochondrion, are transported across the inner mitochondrial membrane by transport proteins and converted into acetyl coa by enzymes in the mitochondrial matrix. Acetyl coa then enters the citric acid cycle/krebs cycle: oxidation of the carbon atoms in acetyl coa produces. Co2, which diffuses out of the mitochondrion to be released to the environment as a waste product: the energy released by the oxidation of acetyl coa is saved in the form of electrons carried by nadh.

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