Biology 2581B Study Guide - Quiz Guide: Total Internal Reflection, Cell Membrane, Cell Cortex
3 Jun 2020
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Ii needs open contractile bundle": however, formins don"t cap could still depolymerise (more dynamic filament. Both nucleators recruited near plasmalemma hence dense filaments juts beneath. Nb depolymerisation promote repolymerisation increase [free subunit: released d actin nt exchange by profilin. Unidirectional movement (specific polarity) along cytoskeletal track. Structure: modular: alter track interaction, motor domain head", tail, atpase, power stroke not coupled with same stage. Actin cytoskeleton not well organised: directionality not useful for directed transport, single head myosin i, functions: contractility (skeletal muscle sliding actin filaments), organelle. 1or 2 actin binding domains; atp hydrolysis: bind actin when binding adp movement. E. g. myosin superfamily: 18+ members: 18+ members: some in all eukarya, some selective, variety cargo possible diverse functions 3, all track > +, except myosin vi. Immobilised biotinylated actin filaments on mica mounted bilayer by streptavidin: visualising: afm: deposited on bilayers, tail-truncated (interested in actin binding heads) myosin v. Myosin viia stereocilia (cochlea) > mutation > deafness.
