Biology 2581B Study Guide - Quiz Guide: Neuromuscular Junction, Schwann Cell, Agrin

• School: Western University
• Department: Biology
• Course: Biology 2581B
• Professor: Susanne Kohalmi

Document Summary

Skeletal muscles contract under the control of the cns. At birth babies can do at least two things, breathing (using diaphragm muscle) and vocalisation (laryngeal muscles). Early steps in the formation of the neuromuscular junction. In the early development of the embryo, the schwann cells migrate to the site where the muscle is forming, and at the same time myotubes are forming from the myoblast. From the neural tube motor axons contact the muscle fibers, on the point of contact a synaptic bouton grows and a terminal schwann cell starts to grow. Clustering of achrs as the neuromuscular junction forms. The nerve must signal to the muscle fibres, so that the muscle fibre can change. The muscle fibres develops junctional folds right where the nerve is in contact with the muscle. Agrin binds to lrp4 and this activates musk which leads to a cluster of achrs post- synaptically.