Biology 3593B Study Guide - Quiz Guide: Hepatitis B Vaccine, 22 Nanometer, Hbsag
Document Summary
Tolerance" neonatal infection: preceded by cirrhosis chronic damage by inflammation / fibrosis, hcc risk plus can transmit. 300m worldwide chronically infected: can survive over a week outside of host. Small 42nm diameter- dna virus reverse transcriptase. Also 22nm lipoprotein particles (envelope plus hbsag) abundant in chronic patient. Pleiomorphic vary in size and shape. The genome: small 3. 2kb circular partially ds dna. 4 orfs extensive overlap use coding potential: overlap evolutionary constraint. Polymerase" reverse transcriptase covers most genome: hbsag 3 flavours differing n termini 2 possible extensions: pres1, pres2. Seroconversion time period during which ab becomes: binds hepatocytes, target for abs and thus ag used in vaccine. [high] plasma chronic: up to 1% plasma protein, but this mainly from the non-infectious lipoprotein particles (22nm: for ab to be detectable, must clear 22nm particles (test negative for detectable in blood. Hbsag when present: x transactivating protein (transcriptional activation)
