Biology 3594A : October 27, 2011 - Prtenjaca et. al

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Mutation frequency is not elevated in the cerebellum of harlequin/big blue mice but class ii deletions occur preferentially in young harlequin cerebellum. Harlequin mouse model: harlequin (hq, xhqy) mouse model is a model of mitochondrial dysfunction leading to elevated oxidative stress and neurodegeneration, contains a proviral insertion in the first intron of the x-linked apoptosis inducing factor (aif) gene. An hqx mouse, with only one copy of the bad gene, ends up losing half of it"s hair. Has retinal degeneration, then cerebellar degeneration, then rod and cone loss and function. At the age of a teenager it looks like a really old mouse. E1---------e2 - between these two, an insertional mutagenesis has been inserted, spontaneous. It is a hypomorph, it is a retrotransposition: the hypothesis is that this is because of an increase in ros. The g10 genotype is the wild type, and shifts from g11 to.

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