Biology 3594A : October 27, 2011 - Prtenjaca et. al

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tanhippopotamus305

15 Dec 2011

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Mutation frequency is not elevated in the cerebellum of harlequin/big blue mice but class ii deletions occur preferentially in young harlequin cerebellum. Harlequin mouse model: harlequin (hq, xhqy) mouse model is a model of mitochondrial dysfunction leading to elevated oxidative stress and neurodegeneration, contains a proviral insertion in the first intron of the x-linked apoptosis inducing factor (aif) gene. An hqx mouse, with only one copy of the bad gene, ends up losing half of it"s hair. Has retinal degeneration, then cerebellar degeneration, then rod and cone loss and function. At the age of a teenager it looks like a really old mouse. E1---------e2 - between these two, an insertional mutagenesis has been inserted, spontaneous. It is a hypomorph, it is a retrotransposition: the hypothesis is that this is because of an increase in ros. The g10 genotype is the wild type, and shifts from g11 to.

Related Questions

DDT is an insecticide that has many effects inside living cells. One of these is to uncouple oxidative metabolism from the generation of ATP - that is, respiration continues, but no ATP is generated. What is the most likely explanation for how this occurs:

A. By increasing the surface area of the inner mitochondrial membrane

B. By increasing the surface area of the outer mitochondrial membrane

C. By increasing the diffusion of H+ through the inner mitochondrial membrane

D.By increasing the diffusion of pyruvic acid through the outer mitochondrial membrane

Please give an explanation for your choice. Thank you!

lemonllama656

1. Compared to the generation of ATP by oxidative phosphorylation, what is a major difference in mechanism of ATP generation by substrate-level phosphorylation in glycolysis?

A. A proton gradient is not involved

B. The ATP produced has less energy content because oxygen was not involved.

C. Substrate level phosphorylation occurs in the inter-mitochondrial space

D. One can't generalize without knowing the substrate.

2. Which of the following statements is true?

A. Because the electrons in NADH are at a higher energy than the electrons in reduced ubiquinone, the NADH dehydrogenase complex can pump more protons than can the cytochrome b-c1 complex.

B.The pH in the mitochondrial matrix is higher than the pH in the intermembrane space.

C. The proton concentration gradient and the membrane potential across the inner mitochondrial membrane tend to work against each other in driving protons from the intermembrane space into the matrix.

D. The difference in proton concentration across the inner mitochondrial membrane has a much larger effect than the membrane potential on the total proton-motive force.

Huntingtons disease (HD) is a rare and fatal neurodegenerative disorder that results in hyperkinesia. One of the issues that occurs as a result of Huntingons's is deficits in axonal transport. For Example, mutations in the huntingtin (Htt) gene result in the loss of anterograde transport of organelles such as mitochondria. Among their many functions, mitochondria are thought to sequester Ca2+ ions. You are working with an animal model of HD. You are recording the responses of neurons receiving synaptic inputs of cells in normal tissue and HD tissue. You note that these responses occur 3-5x more often in the HD tissue than that of normal tissue. Propose a mechansim wherein the Htt mutation could produce this increase in the responses of the HD neurons.

Biology 3594A : October 27, 2011 - Prtenjaca et. al

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