Biology 1002B Study Guide - Taq Polymerase, Tumor Suppressor Gene, Dna-Binding Domain

• School: Western University
• Department: Biology
• Course: Biology 1002B
• Professor: Denis Maxwell

Document Summary

4 most common: prostate, breast, lung, colorectal. Predisposition of inheriting one defective allele increases risk. More environmental progressive and accumulative mutations. G1 checkpoint g1 cyclin e bind to cdk2 to activate protein phosphorylation to allow dna replication: mutations cause no dna replication sterile or allow damage dna to replicate. S phase s cyclin a bind to cdk2 to initiate dna replication. G2 accumulation of m cyclin b bind to cdk1 to activate protein phosphorylation allow g2 checkpoint. Each cyclin is degraded in the next stage. Egf binds to egfr and stimulates growth by signalling gene transcription that promote cell cycling, mitosis: mutation can cause rapid/excessive cell division and can form a tumour. Ways that cells can turn to be cancerous. Tp53 tumor suppressor gene (slow cell cycling in embryology) helps prevent cancer by preventing mutation: prevent g1 checkpoint by initiating apoptosis to get rid of damaged dna and repairing it.