Biology 1002B Study Guide - Final Guide: Stop Codon, Exon Shuffling, Tumor Suppressor Gene

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Characteristics and predictions of the neutral theory of molecular evolution. Selection theory: every mutation affected fitness, most were deleterious, but some were advantages. (because there are more ways to screw up an enzyme than to make it better) Neutral theory: suggests that many mutations are neutral and do not affect fitness. Thus, a smaller amount of mutations is advantageous but also a smaller amount is deleterious. --> i thought most are deleterious. Most still are deleterious but less than the selection theory thought because of the consideration of the neutral mutations. Mechanisms to explain how and why, over evolutionary time, lineages may lose and/or regain genes. Through gene duplication, which encompasses whole-genome duplication, unequal crossing over of homologous chromosomes during meiosis, and replication of transposable elements. Also through exon shuffling, which involves duplication and rearrangement of exons. Exon shuffling can produce genes with extra copies of a domain.

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