Biology 2290F/G : Bio2290F Popular Article Paper Gray Unit

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Technological advances show obesity to be more complex than initially thought. Obesity is a disease resulting from mutations or changes in genes. Figures released form the world health organization estimate that there are 1 billion adults considered overweight, and. 300 million of these meet the definition of clinical obesity. As genetic mutations are inevitable, and incurable, the principal goal is to improve the condition of the obese individual by intervening with therapy. It seems that the success of any proposed interventional therapy will rely heavily upon an understanding of the mechanism under which obesity develops. Listed in order of increasing complexity, these are: monogenetic, syndromic, and polygenic obesity. By the undertaking of experiments based on different hypotheses, the genetics controlling the obese state may be better understood. Deeper insight into the current knowledge of monogenetic, syndromic, and polygenic obesity will delineate the underlying complexity of this disease.

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