Microbiology and Immunology 2500A/B Study Guide - Midterm Guide: Adaptive Immune System, Innate Immune System, Nadph Oxidase
24 Dec 2018
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Document Summary
Phagocytosis is the main way in which we destroy extracellular pathogens. Nadph oxidase - this produces toxic oxygen metabolites as a product of the reaction of. Phagocytes express three different receptors on their surface that act as binding pathways to trigger the process of phagocytosis: pathogen. Prrs , which binds to the pamps on the. Cr1 , which binds to the acute-phase protein c3b that coats the surface of a pathogen. Fc receptors , which binds to the antibodies (ig molecules) that coat the surface of a pathogen. The prr-pamp binding interaction will always occur first because it is part of the innate immune responseresponds to extracellular pathogen immediately. C3b and antibodies are both parts of the adaptive immune response and are not present at the time of the initial exposure to the pathogenneed to be developed. Typically the cr1-c3b binding interaction and the fc receptor-antibody binding interactions are happening simultaneouslythese can take up to two weeks to occur.
