Pharmacology 2060A/B Study Guide - Final Guide: Peroxisome Proliferator-Activated Receptor Alpha, Auditory Hallucination, Muscle Tone
26 Apr 2017
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Module 2: absorption, rate of dissolution, surface area, blood flow to area, lipid solubility, ph partitioning, activity of transport proteins, routes of administration, oral, sublingual, transdermal. Intestine enterocytes that line the gut are able to metabolize drugs: liver primary metabolizing organ, stomach alcohol metabolism, kidney and intestinal bacterial also included, consequences of drug metabolism: In cytosol except ugt: cyp enzymes, 12 families and most important for drug metabolism include. Excretion removal of the parent drug and drug metabolites from the body: removal with kidney, lung, bile, and breast milk. Renal: kidney is a majority of drug excretion, the nephron regulates water, electrolyte, and drug excretion, controls blood volume, blood pressure, blood ph, afferent arteriole to glomerulus, efferent arteriole away from. Glomerular filtration: low molecular weight drugs go into the renal arteriole, 120 ml/min/1. 73 m^2, 20% of renal plasma flow, not affected by lipid solubility or ph, only non-protein bound.
