Pharmacology 2060A/B Study Guide - Final Guide: Losartan, Protamine, G2 Phase
30 Jul 2018
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Inhibits hepatic synthesis of cholesterol by inhibiting hmg coa reductase (converts hmg coa (cid:198) mevalonic acid) Causes upreg of hepatic ldl receptors, lets liver remove more chol from blood (cid:120) Primary prevention of coronary heart disease (effective even in low risk patients w/ no history) Secondary prevention: prevent recurrence of cardiovasc events (effective for higher risk patients) (cid:120) (cid:120) net effects: decreases in [ldl], Since ldl = byproduct of vldl degradation, nicotinic acid reduces. Vldl & ldl (cid:120) net effects: decreases in [vldl], Bind to bile acids (-ve charge), prevent reabsorption (usually, Liver will need to synth more bile acids using cyp7a1 mediated chol metabolism, will take up more ldl from blood to do so (cid:120) net effect: decreased plasma [ldl] (cid:120) Inhibits npc1l1: responsible for intestinal uptake of majority of dietary cholesterol. Largely extracted by liver (cid:120) metabolized by cyp3a4 (cid:120) Distr mostly to liver, also to skeletal musc (cid:120) not extensively metabolized (cid:120) (cid:120)
