Physiology 3130Z Study Guide - Final Guide: Bronchodilator, Diastole, Exhalation

• School: Western University
• Department: Physiology
• Course: Physiology 3130Z
• Professor: Boun Thai

Document Summary

Dexamethosone: glucocorticoid, anti inflammatory drug (used to treat asthma, allergies, cartilage) and then predict the effect on longitudinal growth. arthritis, lupus, etc only used in emergencies now, instead of as a regular treatment because it stunts bone growth) promotes chondrocyte apoptosis reduces bone growth increases expression of pro apoptotic proteins decreases expression of anti apoptotic proteins cgmp: second messenger, downstream effector of cnp long and complicated biochemical pathway that ultimately promotes proliferation of chondrocytes increases bone growth. 1. summarize the physiological function of cortisol and how its synthesis and secretion are regulated [hz1] . Cortisol function: increased blood glucose, gluconeogenesis, muscle catabolism (amino acids), inhibition of glut-4 activity (glucose transport) Regulated by hpa (hypothalamic pituitary adrenal axis) 1. hypothalamus release crh -> stimulate release of acth in anterior pituitary. > stimulate adrenal cortex (zona fasciculate) to make cortisol steroids. Cortisol negative feedback to crh and acth: ie. hypothalamus and pituitary have receptors for cortisol.